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Membrane Transporter/Ion Channel-

BMS-191095????????????ATP????????????mitoKATP?????????????????????????????????

Potassium Channel

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生物活性

Description

BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.Target: potassium channelin vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ?? 2.3%, 31.6 ?? 2.1%, and 39.5 ?? 3.2% relaxation in response to 10, 50, and 100 ??M, respectively. in  vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.

References

[1].Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.