"目录号: HY-13634
Ezatiostat(TER199; TLK199)盐酸盐是谷胱甘肽类似物，是谷胱甘肽s-转移酶（GST）P1-1抑制剂。
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Description
Ezatiostat hydrochloride is a glutathione analog inhibitor ofglutathione S-transferase P1-1 (GSTP1-1).
In Vitro
Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].
Clinical Trial
Telik
Myelodysplastic Syndrome (MDS)
October 2011
Phase 2
Telik
Myelodysplastic Syndrome (MDS)
October 2011
Phase 2
Telik
Severe Chronic Neutropenia
April 2009
Phase 2
Telik
Myelodysplastic Syndrome
November 2009
Phase 1
Telik
Non-small Cell Lung Cancer
October 2008
Phase 2
Telik
Myelodysplastic Syndrome (MDS)
May 2008
Phase 2
Telik
Myelodysplastic Syndrome (MDS)
February 2006
Phase 1-Phase 2
Telik
Myelodysplastic Syndromes
April 2002
Phase 1-Phase 2
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