GREAT predicts functions of cis-regulatory regions.

Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is particularly useful in studying cis functions of sets of non-coding genomic regions. Cis-regulatory regions can be identified via both experimental methods (e.g. ChIP-seq) and by computational methods (e.g. comparative genomics). For more see our Nature Biotech Paper.

News

October 23, 2017: GREAT is being serviced to eliminate proxy errors.

June 22, 2017: GREAT hardware is being upgraded, GREAT will be down for 10-15 minutes

December 7, 2016: GREAT will be down intermittently for hardware relocation.

Feb 15, 2015: GREAT version 3.0 switches to Ensembl genes, adds the mouse mm10 assembly, and adds new ontologies.

Apr 3, 2012: GREAT version 2.0 adds new annotations to human and mouse ontologies and visualization tools for data exploration.

Feb 18, 2012: The GREAT forums are released, allowing increased user-to-user interaction

More news items...