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1. To date, however, no quantitative benchmarks have been proposed to evaluate such methods. 至今；迄今为止
2. Conversely, plate-based platforms usually employ full-length sequencing protocols and, accordingly, allow to sequence a much lower number of single cells (∼hundreds), yet with a considerably higher coverage. adv. 相反地；/adv. 因此，于是；相应地；照着；/conj. 但是；然而 adv. 还；但是；已经
3. Very often, the two categories are mentioned indistinctly (see e.g. [35]), even though they comprise substantially different computational tasks
4. The first one accounts for reducing the bias toward highly expressed genes, by aggregating the expression of similar cells based on the distance between their principal component scores.
5. Lastly, the resulting decomposition is used to impute missing values.
5. Consequently, the true expression X exhibits an approximate lowm rank structure in the sense that there are only a few large singular values followed by many weak ones for the expression matrix.
6. However, tissues are invariably complex, and expression analysis of a tissue confounds the true expression patterns of its constituent cell types.
7. Single-cell RNA-seq expression profiles were generated, and clustered to form a two-dimensional cell map onto which expression data were projected.
8. A diverse array of methods has been proposed to computationally remove noise by sharing information across similar cells or genes, however their respective accuracies have been difficult to establish.
