衰老研究中的明星: 基因&分子&通路

1. NAD+

https://mp.weixin.qq.com/s?__biz=MzU2NDYwMzA1NQ==&mid=2247488197&idx=1&sn=22f091b5e356b1a9955e329d4a68c309&chksm=fc492305cb3eaa13f5145b48350e969241545402f026b88296741d1b86d76f5a1e3581e23e10&mpshare=1&scene=1&srcid=1223bQLaziZPnN6lIQeQTy9i&sharer_shareinfo=ef967ba4eb2894b8316dfe7dd9666f01&sharer_shareinfo_first=ef967ba4eb2894b8316dfe7dd9666f01#rd

2. CD38

https://mp.weixin.qq.com/s?__biz=MzU2NDYwMzA1NQ==&mid=2247488197&idx=1&sn=22f091b5e356b1a9955e329d4a68c309&chksm=fc492305cb3eaa13f5145b48350e969241545402f026b88296741d1b86d76f5a1e3581e23e10&mpshare=1&scene=1&srcid=1223bQLaziZPnN6lIQeQTy9i&sharer_shareinfo=ef967ba4eb2894b8316dfe7dd9666f01&sharer_shareinfo_first=ef967ba4eb2894b8316dfe7dd9666f01#rd

3. ATP

https://mp.weixin.qq.com/s?__biz=Mzg5MDU0NTQ4NA==&mid=2247551178&idx=1&sn=d2e3554daeeb52b91352a7496156ce91&chksm=cfd8bce9f8af35ff22a4a43946db4a6aabe70b1083bf501fbd5685dd58002d15e1ef4507b989&mpshare=1&scene=1&srcid=1226B13WKK3on69CdiwzpL6X&sharer_shareinfo=b2bf58ab3761ef5bcacdeff0fa46541e&sharer_shareinfo_first=b2bf58ab3761ef5bcacdeff0fa46541e#rd

4. Nrf2

https://mp.weixin.qq.com/s?__biz=Mzg5MDU0NTQ4NA==&mid=2247551178&idx=1&sn=d2e3554daeeb52b91352a7496156ce91&chksm=cfd8bce9f8af35ff22a4a43946db4a6aabe70b1083bf501fbd5685dd58002d15e1ef4507b989&mpshare=1&scene=1&srcid=1226B13WKK3on69CdiwzpL6X&sharer_shareinfo=b2bf58ab3761ef5bcacdeff0fa46541e&sharer_shareinfo_first=b2bf58ab3761ef5bcacdeff0fa46541e#rd

5. ROS

https://mp.weixin.qq.com/s?__biz=MzUxMzk5MjY5NA==&mid=2247597079&idx=3&sn=7f16da6d9c8946dcb7afbc6796591f13&chksm=f94f8e8ece38079812daf8b9088c09e0a2d119c62f1accca3685d9a52fa1cff6ec63f2e09c17&mpshare=1&scene=1&srcid=0102z9vFL6C2TK75PoKi7LZd&sharer_shareinfo=a571d34a3bc1e6f18552ad6505553a77&sharer_shareinfo_first=a571d34a3bc1e6f18552ad6505553a77#rd

https://en.wikipedia.org/wiki/Reactive_oxygen_species

6. RSR

核糖体毒性应激反应: Ribotoxic Stress Response

https://academic.oup.com/nar/article/48/19/10648/5907959

https://mp.weixin.qq.com/s?__biz=MzUxMzk5MjY5NA==&mid=2247597079&idx=3&sn=7f16da6d9c8946dcb7afbc6796591f13&chksm=f94f8e8ece38079812daf8b9088c09e0a2d119c62f1accca3685d9a52fa1cff6ec63f2e09c17&mpshare=1&scene=1&srcid=0102z9vFL6C2TK75PoKi7LZd&sharer_shareinfo=a571d34a3bc1e6f18552ad6505553a77&sharer_shareinfo_first=a571d34a3bc1e6f18552ad6505553a77#rd

7. ZAK

Also known as MAP3K20 (mitogen-activated protein kinase kinase kinase 20)

https://www.ncbi.nlm.nih.gov/gene/51776

https://www.ncbi.nlm.nih.gov/gene/51776
There are 2 alternatively spliced forms of ZAK: ZAKα and ZAKβ

https://doi.org/10.1126/science.adf3208

8. p38

Also known as MAPK1 (mitogen-activated protein kinase 1)

https://www.ncbi.nlm.nih.gov/gene/5594

9. JNK

Also known as MAPK8 (mitogen-activated protein kinase 8)

https://www.ncbi.nlm.nih.gov/gene/5599

10. RQC

Ribosome-associated Quality Control

https://academic.oup.com/nar/article/48/19/10648/5907959

11. ISR

Integrated Stress Response

https://academic.oup.com/nar/article/48/19/10648/5907959

12. mTOR

mechanistic target of rapamycin kinase

https://www.ncbi.nlm.nih.gov/gene/2475

https://www.cellsignal.cn/pathways/mtor-signaling-pathway

13. MYC

MYC proto-oncogene, bHLH transcription factor

https://www.ncbi.nlm.nih.gov/gene/4609

This gene positively regulates the expression of ribosomal proteins.

14. C15:0

十五烷酸

15. OXR1

https://www.nature.com/articles/s43587-022-00357-y

16. AMPK

https://www.cellsignal.cn/pathways/ampk-signaling-pathway

17. IL-1β

IL1B: interleukin 1 beta (human)
白细胞介素-1β
https://www.ncbi.nlm.nih.gov/gene/3553

https://zhuanlan.zhihu.com/p/616792564

18. Wnt

19. Hippo

20. JAK/STAT

21. P53

22. SIRT2

https://www.ncbi.nlm.nih.gov/gene/23411