基于片段的药物设计（FBDD）的理论基础是挑选有利的片段组合或延伸得到新药物分子，获得高活性的候选药物，其本质不是筛选已知化合物的类似物，而是培育和设计药物。FBDD方法的前提是建立高品质的片段库，片段分子往往需要满足“三规则”：分子量小于300，氢键供体和受体不超过3（未得到广泛认可），可旋转键数目不超过3，cLogP小于3，此外良好的化学空间多样性也是重要的考察内容。
通用片段库：https://www.tsbiochem.com/library/UORSY%20-%20General%20fragments%20Library
溶解性片段库：https://www.tsbiochem.com/library/UORSY%20-%20Fragments%20with%20solubility%20Library
精选片段库：https://www.tsbiochem.com/library/UORSY%20-%20Selected%20Fragments%20Library
低分子量片段库：https://www.tsbiochem.com/library/Low%20MW%20Fragment%20Library
3D多样性片段库：https://www.tsbiochem.com/library/3D%20Shape%20Diverse%20Fragment%20Library
Mini片段库：https://www.tsbiochem.com/library/MiniFrag%20Library
饱和片段库：https://www.tsbiochem.com/library/UORSY%20-%20Saturated%20Fragments%20Library
二代高端片段库：https://www.tsbiochem.com/library/2nd%20Generation%20Premium%20Fragment%20Library
高溶解性片段库：https://www.tsbiochem.com/library/High%20Solubility%20Fragment%20Library
高保真片段库：https://www.tsbiochem.com/library/High%20Fidelity%20Fragment%20Library
片段库：https://www.tsbiochem.com/library/Fragments%20Library
可溶性片段的多样性筛选子库：https://www.tsbiochem.com/library/Diversity%20Screening%20Subsets%20of%20Soluble%20Fragments
3D片段库：https://www.tsbiochem.com/library/3D-Fragment-Library
通用片段库：https://www.tsbiochem.com/library/Otava%20-%20General%20Fragments%20Library
精选片段库：https://www.tsbiochem.com/library/Featured%20Fragment%20Library
形状多样性片段库：https://www.tsbiochem.com/library/UORSY%20-%20Shaped%20Fragments%20Library
有实验溶解度的片段库：https://www.tsbiochem.com/library/Fragment%20Library%20with%20Experimental%20Solubility
必备片段库：https://www.tsbiochem.com/library/Essential%20Fragment%20Library
富含Fsp3的片段库：https://www.tsbiochem.com/library/Fsp%C2%B3-enriched%20Fragment%20Library
天然产物类似片段库：https://www.tsbiochem.com/library/Natural%20Product-like%20Fragments
天然产物类似的片段库：https://www.tsbiochem.com/library/Natural%20Product-like%20Fragment%20Library
药物片段库：https://www.tsbiochem.com/library/Drug-Fragment%20Library
PPI 片断库：https://www.tsbiochem.com/library/PPI-Fragment-Library
羧酸片段库：https://www.tsbiochem.com/library/Carboxylic%20Acid%20Fragment%20Library
DSI专用库：https://www.tsbiochem.com/library/DSI-poised%20Library
全功能化探针库：https://www.tsbiochem.com/library/Fully%20Functionalized%20Probe%20Library
蛋白相互作用片段库：https://www.tsbiochem.com/library/PPI%20Fragment%20Library
螯合剂片段库：https://www.tsbiochem.com/library/Chelator%20Fragment%20Library
天然片段库：https://www.tsbiochem.com/library/FRGx%20Fragments%20from%20Nature%20Libray
单药效团片段库：https://www.tsbiochem.com/library/Single%20Pharmacophore%20Fragments
含氟片段库：https://www.tsbiochem.com/library/Otava%20-%20Fluorine%20Fragment%20Library
含溴片段库：https://www.tsbiochem.com/library/Otava%20-%20Halogen-Enriched%20Fragments
含氟与含溴片段库：https://www.tsbiochem.com/library/Crystallographic%20and%2019F%20NMR%20fragment-libraries
螯合剂片段库：https://www.tsbiochem.com/library/Otava%20-%20Chelator%20Fragment%20Library
含氟片段Cocktail：https://www.tsbiochem.com/library/Fluorine%20Fragment%20Cocktails
赖氨酸靶向共价片段库：https://www.tsbiochem.com/library/Lysine%20focused%20Covalent%20Fragments
硼酸片段库：https://www.tsbiochem.com/library/Boronic%20Acid%20Fragments
丝氨酸靶向共价片段库：https://www.tsbiochem.com/library/Serine%20focused%20Covalent%20Fragments
共价片断库：https://www.tsbiochem.com/library/Covalent-Fragment-Library
半胱氨酸靶向共价片段库：https://www.tsbiochem.com/library/Cysteine%20focused%20Covalent%20Fragments
特异性共价抑制剂片段库：https://www.tsbiochem.com/library/Specific%20Covalent%20Inhibitor%20Fragment%20Library
Smart共价片段库：https://www.tsbiochem.com/library/Smart%20Library%20of%20Covalent%20Fragments
