"目录号: HY-14839

GPCR/G Protein-

Evatanepag (CP-533536) 是一种EP2受体选择性的前列腺素E2 (PGE2) 激动剂, 诱导局部骨形成, EC50为0.3 nM。

Prostaglandin Receptor

相关产品

Prostaglandin E1-Grapiprant-NS-304-TG6-10-1-Terutroban-Latanoprost-PF-04418948-Dinoprost tromethamine salt-Iloprost-ONO-AE3-208-Bimatoprost-Laropiprant-Setipiprant-AH 6809-CJ-42794-

生物活性

Description

Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.IC50 value: 0.3 nM (EC50)Target PGE2in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.

References

[1].Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8.