"目录号: HY-15195
GPCR/G Protein-
Avosentan(Ro 67-0565; SPP-301)是内皮素（ETA）受体拮抗剂。
Endothelin Receptor
相关产品
Macitentan-Atrasentan hydrochloride-BQ-788 sodium salt-Bosentan-Ambrisentan-BQ-123-ACT-132577-Sitaxsentan sodium-Sulfisoxazole-Zibotentan-Endothelin 1 swine, human-Aminaftone-PD-159020-Ro 46-2005-ZD-1611-
生物活性
Description
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.IC50 value:Target: ETA receptor
References
[1].Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA. Antidiuretic effects of the endothelin receptor antagonist avosentan. Front Physiol. 2012;3:103.
[2].Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J. Effect of avosentan (SPP-301) in porcine ciliary arteries. Curr Eye Res. 2011 Feb;36(2):118-24.
[3].Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group. J Am Soc Nephrol. 2010 Mar;21(3):527-35.
[4].Dieterle W, Hengelage T. Absolute bioavailability and pharmacokinetics of avosentan in man. Int J Clin Pharmacol Ther. 2009 Sep;47(9):587-94.
[5].Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.
