"目录号: HY-15204
Tonabersat 是一种gap-junction调节剂。
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Description
Tonabersat is agap-junctionmodulator.
IC50& Target
Gap-junction[1]
In Vitro
Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms[1].
In Vivo
Treatment with either Tonabersat (10 mg/kg) or Meclofenamate (20 mg/kg) as single agents significantly inhibit progression of metastatic lesions. Addition of carboplatin to either agent profoundly inhibits brain metastasis[2].
Clinical Trial
Minster Research Ltd
Migraine Without Aura-Migraine With Aura
April 2006
Phase 2
Minster Research Ltd
Migraine Without Aura-Migraine With Aura
October 2007
Phase 2
Minster Research Ltd-University of Copenhagen
Migraine With Aura
May 2006
Phase 2
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References
