Alessandro Gozzi
意大利科学家,关注小动物功能磁共振成像,在基因缺失动物fMRI、光遗传fMRI、药理调控fMRI、脑网络构建方面均有建树。2019年,大量研究开始转向共激活模式,解析大脑瞬时活动状态,在脑功能解释、疾病分析、跨物种研究中的意义。
https://www.researchgate.net/profile/Alessandro-Gozzi-3
Introduction
The Gozzi lab (tinyurl.com/3dypjwkp) focuses on the study of **mammalian brain **organization at the macroscale. Our ultimate goal is to understand how the brain works as an integrated network, both in healthy and in pathological states. To achieve our goals, we combine cross-species measures of network activity (i.e., fMRI, fUS) with chemogenetics, optogenetics, large-scale electrophysiology and advanced computational modelling.
- Infraslow State Fluctuations Govern Spontaneous fMRI Network Dynamics
- July 2019
- Current Biology 29(14)
- DOI:
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10.1016/j.cub.2019.06.017
共激活模式早在2012年就已提出,但一直以来关注较少。Alessandro Gozzi等人的研究再次将CAP带入到视野中央。在这篇文章里,除了华丽的作图技巧外(大脑切片图可通过mricrogl制作),最有趣的事情来源于文章提供的几点新知:
1)CAP模式通常呈对出现,两两表现出空间负相关;
2)CAP持续时间在5s左右;
3)CAP的主要活动范围在0.01-0.03Hz之间;
4)CAP活动可以看作是正弦波的不同区段
5)CAP活动与功能连接强度紧密相关
- Unique spatiotemporal fMRI dynamics in the awake mouse brain
- January 2022
- Current Biology 32(3)
- DOI:
-
10.1016/j.cub.2021.12.015
2022年,麻醉剂对脑瞬时状态的影响
- Mapping and comparing fMRI connectivity networks across species
- December 2023
- Communications Biology 6(1)
- DOI:
-
10.1038/s42003-023-05629-w
跨物种研究的几种策略
- Modular subgraphs in large-scale connectomes underpin spontaneous co-fluctuation events in mouse and human brains
- January 2024
- Communications Biology 7(1)
- DOI:
- 10.1038/s42003-024-05766-w
- Evolutionarily conserved fMRI network dynamics in the mouse, macaque and human brain
- February 2024
- DOI:
- 10.21203/rs.3.rs-3879491/v1