openpyxl

The recommended package for reading and writing Excel 2010 files (ie: .xlsx)

xlsxwriter

An alternative package for writing data, formatting information and, in particular, charts in the Excel 2010 format (ie: .xlsx)

xlrd

This package is for reading data and formatting information from older Excel files (ie: .xls)

xlwt

This package is for writing data and formatting information to older Excel files (ie: .xls)

xlutils

This package collects utilities that require both xlrd and xlwt, including the ability to copy and modify or filter existing excel files.
NB: In general, these use cases are now covered by openpyxl!

总结来说用openpyxl没错的