Naive and Primed Pluripotent States - ScienceDirect

摘要：

After maternal predetermination gives way to zygotic regulation, a ground state is established within the mammalian embryo. This tabula rasa for embryogenesis is present only transiently in the preimplantation epiblast. Here, we consider how unrestricted cells are first generated and then prepared for lineage commitment. We propose that two phases of pluripotency can be defined: naive and primed. This distinction extends to pluripotent stem cells derived from embryos or by molecular reprogramming ex vivo.
在母源预先决定让位给合子调节后，哺乳动物胚胎内建立基态。这种胚胎发生的白纸般的状态只在着床前的上胚层中短暂存在。在这里，我们考虑如何首先生成无限制细胞，然后为谱系分化做好准备。我们提出可以定义多能性的两个阶段：原始态和始发态。这种区别延伸到从胚胎或体外分子重编程获得的多能干细胞。

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