image.png

以下为代码：

graph TB
    subgraph Central_Metabolism
        direction TB
        subgraph Glycolysis_Gluconeogenesis
            A[Glucose] -->|HK| B[Glucose-6-phosphate]
            B -->|GPI| C[Fructose-6-phosphate]
            C -->|PFKL/PFKM| D[Fructose-1,6-bisphosphate]
            D -->|ALDOA/B/C| E[Glyceraldehyde-3-phosphate]
            E -->|TPI1| F[Dihydroxyacetone phosphate]
            E -->|GAPDH| G[1,3-Bisphosphoglycerate]
            G -->|PGK1| H[3-Phosphoglycerate]
            H -->|PGAM1| I[2-Phosphoglycerate]
            I -->|ENO1| J[Phosphoenolpyruvate]
            J -->|PKM| K[Pyruvate]
            K -->|PDH| L[Acetyl-CoA]
            L -->|PC| M[Oxaloacetate]
            M -->|PCK1/2| J
            B -->|G6PC| A
        end

        subgraph TCA_Cycle
            L -->|CS| N[Citrate]
            N -->|ACO1/2| O[Isocitrate]
            O -->|IDH1/2/3| P[α-Ketoglutarate]
            P -->|OGDH| Q[Succinyl-CoA]
            Q -->|SUCLG1/2| R[Succinate]
            R -->|SDHA/B/C/D| S[Fumarate]
            S -->|FH| T[Malate]
            T -->|MDH1/2| M
        end

        subgraph Fatty_Acid_Metabolism
            L -->|ACACA| U[Malonyl-CoA]
            U -->|FASN| V[Palmitate]
            V -->|ACSL1/3/4/5/6| W[Palmitoyl-CoA]
            W -->|CPT1A/B| X[Palmitoylcarnitine]
            X -->|SLC25A20| Y[Palmitoylcarnitine in mitochondria]
            Y -->|CPT2| Z[Palmitoyl-CoA in mitochondria]
            Z -->|ACAD family| AA[Acetyl-CoA]
            AA --> L
        end

        subgraph Mevalonate_Pathway
            L -->|ACAT1/2| AC[Acetoacetyl-CoA]
            AC -->|HMGCS1/2| AD[HMG-CoA]
            AD -->|HMGCR| AE[Mevalonate]
            AE -->|MVK| AF[Mevalonate-5-phosphate]
            AF -->|PMVK| AG[Mevalonate-5-pyrophosphate]
            AG -->|MVD| AH[Isopentenyl pyrophosphate]
            AH -->|Multiple steps| AI[Cholesterol]
        end

        subgraph Amino_Acid_Synthesis
            AJ[Glucose] --> AK[3-Phosphoglycerate]
            AK -->|PHGDH/PSAT1/PSPH| AL[Serine]
            AL -->|SHMT1/2| AM[Glycine]
            K -->|GPT| AN[Alanine]
            M -->|GOT1/2| AO[Aspartate]
            AO -->|ASNS| AP[Asparagine]
            P -->|GLUD1/2| AQ[Glutamate]
            AQ -->|GLUL| AR[Glutamine]
        end
    end

    %% Styling
    classDef centralMetabolism fill:#f0f0f0,stroke:#333333,stroke-width:2px;
    classDef glycolysis fill:#e6f3ff,stroke:#4169e1,stroke-width:2px;
    classDef tca fill:#fff5eb,stroke:#ff7f50,stroke-width:2px;
    classDef fattyAcid fill:#f0e6ff,stroke:#9932cc,stroke-width:2px;
    classDef mevalonate fill:#ffe6f3,stroke:#ff1493,stroke-width:2px;
    classDef aminoAcid fill:#f3e6d8,stroke:#8b4513,stroke-width:2px;

    class Central_Metabolism centralMetabolism;
    class A,B,C,D,E,F,G,H,I,J,K,L,M glycolysis;
    class L,N,O,P,Q,R,S,T,M tca;
    class L,U,V,W,X,Y,Z,AA fattyAcid;
    class L,AC,AD,AE,AF,AG,AH,AI mevalonate;
    class AJ,AK,AL,AM,K,M,AO,AP,P,AQ,AR aminoAcid;

    %% Legend
    subgraph Legend
        z0[Central Metabolism]
        z1[Glycolysis/Gluconeogenesis]
        z2[TCA Cycle]
        z3[Fatty Acid Metabolism]
        z4[Mevalonate Pathway]
        z5[Amino Acid Synthesis]
    end

    class z0 centralMetabolism;
    class z1 glycolysis;
    class z2 tca;
    class z3 fattyAcid;
    class z4 mevalonate;
    class z5 aminoAcid;