高脂溶性α-螺旋两亲性细胞穿透肽与磷脂结合用于发展肺表面活性剂模型系统。Hel 13-5也能与核酸结合。CPP是一种最有效的DNA和siRNA传递和转染剂。
编号:200151
中文名称:Hel 13-5
CAS号:177942-21-1
单字母:H2N-KLLKLLLKLWLKLLKLLL-OH
三字母:H2N-Lys-Leu-Leu-Lys-Leu-Leu-Leu-Lys-Leu-Trp-Leu-Lys-Leu-Leu-Lys-Leu-Leu-Leu-COOH
氨基酸个数:18
分子式:C113H204N24O19
平均分子量:2202.98
精确分子量:2201.57
等电点(PI):11.41
pH=7.0时的净电荷数:4.97
平均亲水性:-0.55555555555556
疏水性值:1.4
来源:人工化学合成，仅限科学研究使用，不得用于人体。
储存条件:负80℃至负20℃
标签:细胞穿膜肽CPPs
参考文献：
10.1016/j.bpj.2008.11.022Pulmonary surfactant model systems catch the specific interaction of an amphiphilic peptide with anionic phospholipid
10.1016/j.bbamem.2014.04.024Improvement of pulmonary surfactant activity by introducing D-amino acids into highly hydrophobic amphiphilic α-peptide Hel 13-5
10.1021/bi961289tDesign and synthesis of amphiphilic alpha-helical model peptides with systematically varied hydrophobic-hydrophilic balance and their interaction with lipid- and bio-membranes
10.1006/bbrc.1998.8408Importance of hydrophobic region in amphiphilic structures of alpha-helical peptides for their gene transfer-ability into cells
