文献DOI：10.2165/11599200-000000000-00000

文献PMID：22329607

文献原文链接：http://doi.org.sci-hub.tw/10.2165/11599200-000000000-00000

Drugs R D 2012; 12 (1): 29-34 

《Combination of Alpha Lipoic Acid and Superoxide Dismutase Leads to Physiological and Symptomatic Improvements in Diabetic Neuropathy》

硫辛酸和超氧化物歧化酶的组合导致糖尿病性神经病变的生理和症状改善

【Abstract】

Background and Objective: The management of diabetic neuropathy is still a challenge for physicians. The aim of this study was to assess the efficacy of a new combination of alpha lipoic acid and superoxide dismutase for the treatment of diabetic neuropathy.

Methods: The setting of this study was ambulatory (outpatient) care. A prospective, non-randomized, open-label study was conducted in 50 patients with diabetes mellitus and with a deficit in both motor and sensory nerve conduction. Treatment was with a new combination of alpha lipoic acid and superoxide dismutase (ALA600SOD) for 4 months. Electroneurographic parameters and perceived pain were assessed at baseline and after treatment.

Results: After 4 months of treatment, patients significantly (p < 0.001) improved their electroneurographic parameters and their perception of pain. Best improvements were observed in sensory nerve conduction.

Conclusion: The combination of two powerful antioxidant agents leads to improvement in both subjective and objective parameters in patients with diabetic neuropathy. New profitable directions for investigations are opened for a non-invasive treatment of diabetic neuropathy in the future.

摘要翻译：

背景和目的：糖尿病神经病变的治疗对医生来说仍然是一个挑战。本研究的目的是评估新的α硫辛酸和超氧化物歧化酶联合用于治疗糖尿病神经病变的疗效。

方法：本研究的设置是门诊（门诊）护理。一项前瞻性、非随机、开放性研究在50名糖尿病患者中进行，这些患者的运动和感觉神经传导方面均存在缺陷。使用α硫辛酸和超氧化物歧化酶（ALA600SOD）的新组合治疗4个月。在基线和治疗后评估电神经参数和感知疼痛。

结果：治疗4个月后，患者显着（p <0.001）改善了他们的神经电图参数和疼痛感。在感觉神经传导中观察到最佳改善。

结论：两种强效抗氧化剂的结合可以改善糖尿病神经病变患者的主观和客观参数，这为将来的糖尿病神经病变的非侵入性治疗开辟了新的有利可图的调查方向。