"目录号: HY-15314
Metabolic Enzyme/Protease-
Ranirestat (AS-3201)是醛糖还原酶抑制剂，糖尿病性神经病变临床3期。
Aldose Reductase
相关产品
Isoliquiritigenin-Epalrestat-Tolrestat-Aldose reductase-IN-1-Alrestatin-IMIRESTAT-RISARESTAT-
生物活性
Description
Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
Clinical Trial
NCT00101426
Sumitomo Dainippon Pharma Co., Ltd.
Diabetic Neuropathy
October 2004
Phase 3
NCT00101426
Sumitomo Dainippon Pharma Co., Ltd.
Diabetic Neuropathy
October 2004
Phase 3
NCT00927914
Eisai Inc.
Mild to Moderate Diabetic Sensorimotor Polyneuropathy.
July 2009
Phase 2-Phase 3
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References
[1].Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7
[2].Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10.
[3].Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.
