[non-silent somatic mutation]non-silent somatic mutation非沉默突变包含哪些类型的突变？

先前在文章“Correlation of Somatic Mutation and Expression Identifies Genes Important in Human Glioblastoma Progression and Survival”中看到了一个词“non-silent”，non-silent somatic mutation到底包含哪些类型的突变？-然而在百度或者bing上搜索并未搜索一个确定的结果

于是我就到各个文章上搜non-silent mutation，没有搜索到完整的结果：Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.提到

• We identified a total of 1,596 non-silent mutations, including 1,312 missenses, 85 nonsenses, 25 splice-site variants and 174 insertions or deletions in those 69 PDPCs

• 在ucsc上搜索GBM的突变数据时，突变数据描述信息上给出这样的信息
  a non-silent somatic mutation (nonsense, missense, frame-shif indels, splice site mutations, stop codon readthroughs, change of start codon, inframe indels) was identified in the protein coding region of a gene, or any mutation identified in a non-coding gene.

所以non-silent包含

• nonsense,
• missense,
• frame-shif indels
• splice site mutations,
• stop codon readthroughs
• change of start codon
• inframe indels -from ucsc
• insertions or deletions -from《Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.》

可能上方列出的non-silent mutation不是最全的，如果你觉的还包含哪些类型的突变，请在评论区留言，写出你的看法和参考资料

注：ucsc xena提供了non-silent somatic mutation ，它是gene-level的突变矩阵：行是基因，列是样本，值为1的是突变。

ucsc xena