"目录号: HY-14187
Membrane Transporter/Ion ChannelAutophagy-
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
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Description
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. Target: Potassium ChannelAmiodarone shows beta blocker-like and potassium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects. Amiodarone (2-butyl, 3-(4-diethylaminoethoxy, 3,5-diiodo, benzoyl) benzofuran hydrochloride), an anti-anginal drug which causes coronary dilatation and depresses myocardial oxygen consumption, was found to protect anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation.2. A 5% (73.4 mM) solution of amiodarone had no local anaesthetic action on guinea-pig skin [1]. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect [2].
Clinical Trial
University Medical Center Groningen
Persistent Atrial Fibrillation
August 2000
Phase 4
Population Health Research Institute-St. Jude Medical-Hamilton Health Sciences Corporation
Defibrillators, Implantable-Tachycardia, Ventricular
August 2010
Phase 3
University of Louisville
Atrial Fibrillation-Lung Transplant; Complications
August 1, 2017
Phase 2
Weill Medical College of Cornell University
Cardiac Disease
March 2012
The University of Texas Health Science Center at San Antonio
New Onset Atrial Fibrillation-Severe Sepsis-Septic Shock
May 2016
Phase 4
Western Galilee Hospital-Nahariya
Atrial Fibrillation
May 2013
Phase 3
Beth Israel Deaconess Medical Center
Atrial Fibrillation-Lung Cancer
February 2006
Phase 3
Aarhus University Hospital
Atrial Fibrillation
August 2008
Phase 4
Baystate Medical Center
Atrial Fibrillation
October 2011
Eastbourne General Hospital
Atrial Fibrillation
March 2011
Texas Cardiac Arrhythmia Research Foundation-University of Kansas-California Pacific Medical Center-Stanford University-Case Western Reserve University-Southlake Regional Health Centre-Catholic University, Italy
Atrial Fibrillation
October 2010
Phase 3
Fundación Cardioinfantil Instituto de Cardiología-Instituto de Corazón de Bucaramanga
Chagas Cardiomyopathy
June 12, 2017
Phase 3
Cardiome Pharma
Atrial Fibrillation
April 2008
Phase 3
St. Jude Medical
Atrial Fibrillation
July 2011
Sanofi
Atrial Fibrillation
June 2007
Phase 3
InCor Heart Institute-Ministry of Health, Brazil-St. Jude Medical-Fundação de Amparo à Pesquisa do Estado de São Paulo
Chagas Cardiomyopathy-Non-sustained Ventricular Tachycardia-At Least 10 Points in Rassi Risk Score for Death
October 2014
Mayo Clinic
Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
November 2007
Centre Hospitalier Universitaire, Amiens
Supraventricular Tachycardia
September 6, 2016
Phase 2
Emergency NGO Onlus
Ebola Virus Disease
December 2014
Phase 2-Phase 3
Kuopio University Hospital-Tampere University Hospital-Vaasa Central Hospital, Vaasa, Finland
Atrial Fibrillation-Cardiac Surgery
August 2007
Phase 4
Texas Cardiac Arrhythmia Research Foundation-Casa Sollievo della Sofferenza IRCCS-Catholic University, Italy-Southlake Regional Health Centre-Stanford University-University of Kansas-The University of Texas Medical Branch, Galveston-University of Foggia-Sutter Health
Heart Failure
October 2008
Phase 4
Memorial Sloan Kettering Cancer Center-Washington University School of Medicine-The Cleveland Clinic-Vanderbilt University School of Medicine
Thoracic Surgery-Atrial Fibrillation in High Risk Patients
April 2016
Phase 3
Cardiome Pharma
Atrial Fibrillation
September 2012
Phase 4
University Medical Center Groningen-Netherlands Heart Foundation
Persistant Atrial Fibrillation
January 2003
University of Washington-National Heart, Lung, and Blood Institute (NHLBI)-Canadian Institutes of Health Research (CIHR)-Heart and Stroke Foundation of Canada-American Heart Association-Defence Research and Development Canada-U.S. Army Medical Research and Materiel Command
Cardiac Arrest
May 2012
Phase 3
Prism Pharmaceuticals
Blood Pressure
August 2008
Phase 2
Guy Amit-Population Health Research Institute
Atrial Fibrillation
January 2016
Phase 4
Inova Health Care Services
Atrial Fibrillation
January 2011
Shiraz University of Medical Sciences
Atrial Fibrillation
March 2007
University of Calgary-Heart and Stroke Foundation of Canada-Wyeth is now a wholly owned subsidiary of Pfizer
Atrial Fibrillation
February 1999
Phase 3
Boehringer Ingelheim
Healthy
April 2006
Phase 1
Rigshospitalet, Denmark
Atrial Fibrillation
January 2009
Rambam Health Care Campus
Atrial Fibrillation
March 2016
Phase 3
Hospital General Universitario Gregorio Marañon
Ventricular Tachycardia-Wide QRS Tachycardia
September 2005
Phase 4
Icahn School of Medicine at Mount Sinai-Biosense Webster, Inc.
Ventricular Tachycardia
October 2009
Sanofi
Arrhythmia Prophylaxis-Ventricular Arrhythmia
September 2009
Phase 2
Hartford Hospital-Gilead Sciences
Arrhythmia
February 2011
Indiana University-Purdue University-Indiana University Health
Atrial Fibrillation-Esophagectomy
September 2005
Phase 4
Charles University, Czech Republic
Supraventricular Arrhythmia-Septic Shock
February 2017
Phase 4
Centre Hospitalier Universitaire de Saint Etienne-Ministry of Health, France
Mitral Valvulopathy-Atrial Fibrillation
March 2012
Indiana University-Purdue University
Atrial Fibrillation
September 2004
Phase 4
VA Office of Research and Development
Atrial Fibrillation-Cerebrovascular Accident-Death, Sudden
April 1998
Phase 3
Ottawa Hospital Research Institute-Heart and Stroke Foundation of Ontario
Atrial Fibrillation
July 2007
Phase 4
Maine Medical Center
Atrial Fibrillation-Atrial Flutter
August 2009
Phase 3
Hunter Holmes Mcguire Veteran Affairs Medical Center-Virginia Commonwealth University-University of California, San Francisco-Univeristy of Calgary-University of Pittsburgh-Wake Forest University Health Sciences
Ventricular Premature Beats, Contractions, or Systoles-Cardiomyopathies
September 1, 2017
Phase 4
University of Aarhus
Atrial Fibrillation-Coronary Artery Bypass Grafting
January 2004
Phase 4
