R-(-)-Deprenyl hydrochloride

"目录号: HY-14199

Neuronal Signaling-

R-(-)-Deprenyl盐酸盐是不可逆的MAO-B选择性抑制剂。

Monoamine Oxidase

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生物活性

Description

R-(-)-Deprenyl Hydrochloride is a selective inhibitor of monoamine oxidase B (MAO-B).Target: Monoamine oxidase B(-)-Deprenyl (selegiline) is an irreversible inhibitor of monoamine oxidase (MAO) B. (-)-Deprenyl in much lower concentrations needed to induce MAO-B inhibition (10(-9) to 10(-13) M) potently inhibits MPTP or serum withdrawal induced apoptosis in tissue cultures of neuro-ectodermal origin (PC12, M1, M2058) [1]. when locomotor activity induced by levodopa was examined on a rodent model of Parkinson's disease, pretreatment of the animals with nonselective doses of deprenyl caused an enhancement of the antiparkinsonian action of levodopa [2]. (-)Deprenyl is a highly potent and selective, irreversible inhibitor of B-type monoamine oxidase (MAO), a predominantly glial enzyme in the brain. The activity of this enzyme significantly increases with age. (-)Deprenyl, the first selective inhibitor of MAO-B described in the literature, has become a universally used research tool for selectively blocking B-type MAO and is still the only selective MAO-B inhibitor in world wide clinical use [3].

References

[1].Mercuri, N.B., et al., Modification of levodopa responses by deprenyl (selegiline): an electrophysiological and behavioral study in the rat relevant to Parkinson's disease. Ann Neurol, 1998. 43(5): p. 613-7.

[2].Magyar, K. and B. Szende, (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology, 2004. 25(1-2): p. 233-42.

[3].Knoll, J., [History of deprenyl--the first selective inhibitor of monoamine oxidase type B]. Vopr Med Khim, 1997. 43(6): p. 482-93.