"目录号: HY-13984
JAK/STAT SignalingProtein Tyrosine Kinase/RTK-
Mutant EGFR inhibitor是选择性EGFR突变型抑制剂，对L858R活化突变型，Exonl9缺失活化突变型和T790M抗性突变型有效。
相关产品
AZD-9291-Gefitinib-Lapatinib-Afatinib-Erlotinib-AG-490-Genistein-AG-1478-Neratinib-EGF816-Olmutinib-AZD3759-Dacomitinib-Irbinitinib-CO-1686-
生物活性
Description
Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor(L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant).IC50 value: Target: Mutated EGFRPreparation of 2-(2,4,5-substituted-anilino)pyrimidine derivatives as EGFR modulators useful for treating cancer.By Butterworth, Sam; Finlay, Maurice Raymond Verschoyle; Ward, Richard Andrew; Kadambar, Vasantha Krishna; Chandrashekar, Reddy C.; Murugan, Andiappan; Redfearn, Heather Marie From PCT Int. Appl. (2013), WO 2013014448 A1 20130131.
