序列(三字母)：
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
序列(单字母)：
DRVYIHPFH
分子式:
C56H78N16O13
分子量:
1183.34
CAS#:
34273-12-6
合成方法：
Synthetic
存储条件：
-20 °C，避光，干燥
应用：
Cardiovascular System & Diseases
产品描述：
Angiotensin I (1-9)在体内被发现，在ACE抑制剂处理过的动物体内聚集。研究显示，angiotensin I (1-9)可能是在内皮细胞-关联的ACE2的作用下由心脏和肾脏产生。Kramkowski等人发现在血小板中从Ang I产生的angiotensin I (1-9)能够增强老鼠血栓的形成。
参考文献:
1. Differential regulation of angiotensin peptide levels in plasma and kidney of the rat. Campbell, DJ; et al., Hypertension, 18, 763, (1991);
2. Differential Regulation of Angiotensin Peptides in Plasma and Kidney: Effects of Adrenalectomy and Estrogen Treatment. Campbell, DJ; et al., Clin. Exp. Hypertens., 19, 687, (1997);
3. A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9. Donoghue, M; et al., Circ. Res., 87, E1, (2000).
4. Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction Fattah, C, et al., J. Am. Coll. Cardiol., 68, 2652, (2016);
5. Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor Cha, SA, et al., Korean J. Physiol. Pharnacol., 22, 447, (2018).
