4E1RCat

"目录号: HY-14427

Cell Cycle/DNA Damage-

4E1RCat能抑制eIF4E与eIF4G的相互作用及eIF4E与4E-BP1的相互作用，可抑制eIF4G和eIF4E的结合，IC50为3.2 μM。

Eukaryotic Initiation Factor (eIF)

相关产品

SBI-0640756-

生物活性

Description

4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.IC50 value: 3.2 uM [1]Target: eIF4E/eIF4G inhibitorIn in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.

References

[1].Liao G, et al. Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts.  PLoS One. 2013 Jun 28;8(6):e68190.