The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program [Circulation Rearch]

GSEA

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转录因子绑定百分比

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SE区域乙酰化信号和TF绑定信号求相关

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展示SE相关特殊基因

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反向GSEA 用TF寻找SE

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Chipseeker 输入BED文件

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Chip-seq信号+Homer motif扫描

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Homer DiffBind 求差异峰定量 ；DiffBind出矩阵

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区域疾病突变富集 ERG super-enhancers prioritize cardiovascular disease variants. (A) Overlap of GWAS SNPs associated with disease trait classes within ERG defined SE (orange) with chromosome and size matched random SE (gray). Significance of enrichment was calculated by binomial distribution test with red dashed line indicating P = 0.05. Some points overlay. (B) Test for enrichment of selected CVD traitassociated SNPs within ERG defined SE (orange) with chromosome and size matched random SE (gray), as performed in A. Random region were restricted to open chromatin by excluding placement in repressed chromatin states in HUVEC

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TF chipseq数据；敲降数据；H3K27ac数据；