29934437 has received increasing attention reside in the human gut numerous studies have reported The human gut microbiota is viewed as a potential source of novel therapeutics remarkably the onset of a disease疾病的发作 This last part of the review is dedicated to a discussion of critical issues and the necessity to develop well-defined experiments 这篇评论的最后一部分致力于讨论一些关键问题，以及在声称某些微生物有益或有害之前，开展定义明确的实验的必要性 deleterious有害的 remain time consuming and fastidious 保持费时和挑剔 On top of that, at the level of our knowledge, it is still very difficult to fully decipher the role of 除此之外，很难完全破解什么，This last point is illustrated最后一点是阐明 in two independent elegant studies 在独立优雅的研究中 seminal papers 开创性的论文 in mouse intervention studies 在小鼠干预实验 in the portal vein of the mice 在小鼠的门静脉 glucose homeostasis 血糖稳态 inversely、Conversely 相反地 this bacterium might be of interest. 这种细菌可能是有趣的，on the ingestion of a high-fat high-sucrose diet 高糖高脂饮食 liver steatosis 脂肪变性 reinforcement of the gut barrier肠道屏障的增强 bariatric surgery减肥手术 With regard to immunity在免疫治疗方面 in a series of recent studies，在一系列的研究中，Specifically,具体来说，poorly responding mice反应差的小鼠，we may not rule out that 我们不能排除什么，drive the beneficial effects.驱动有益影响 Moreover此外，Strikingly令人吃惊的是，studies elegantly demonstrated that研究很好的证明了什么 worsened 恶化了什么 Consequently,因此，Along this line沿着这一思路，few of these papers dissected 很少的文章解析过---seminal studies开创性研究， flawed有缺陷的，predominant factors主要因素，a tremendous amount of microorganisms大量的微生物，However, we must acknowledge that 然而，我们必须承认--
are key contributors to什么是关键因素 Undeniably 不可否认的是，Moreover, the current understanding is ，此外，目前的认识是，A large number of recent papers and reviews have covered different aspects of the 大量论文都涉及--，scrutinise 仔细检查， caveats 警告
