Today, we're excited to introduce you to the Liposome Hand Extruder by Genizer. This tool is designed to remove particles and precipitates from products, reduce particle size of liposomes and emulsions, and make aseptic filtration easier. It's particularly useful for ultra-small volume applications during the experimental stage. The power source is manually operated.

To use the extruder, simply push the plunger of the syringe to generate a certain amount of force that pushes the sample repeatedly through the extrusion membrane, which has a defined pore size. This process results in the preparation of liposomes ranging from 20 to 400 nanometers.

Let's take a closer look at the structure of the extruder. It consists of several parts, including the extruder housing, extrusion membrane, O-Ring Seal, O-Ring Bracket, Micron Orifice/Pore Plate, Container Nut, and Stabilizer Bracket.

To assemble the extruder, start by inserting the micron pore/orifice plate into the O-ring support with the dull side facing up. Then, place the extrusion membranes evenly between two O-ring brackets. Finally, screw on the container nut, being careful not to move the extrusion membrane. Tighten the nut by hand until you feel noticeable resistance.

To prepare the material, draw 1ml of the sample into a syringe and screw it onto one side of the extruder. Repeat this step for the other side. Then, place the entire assembly into the groove of the stabilizer and put on the plastic top cover. Tighten the nuts on the stabilizer to secure it in place.

When you're ready to start extruding, gently push the plunger of the gas-tight syringe containing the sample to begin the process. It's important to apply even pressure and keep the force directed along the syringe to prevent the glass housing from cracking or becoming damaged.

After extruding in one direction, switch the syringe position and continue extruding from the other direction until the desired particle size is achieved. Typically, around 10 passes of extrusion are necessary to reach the desired size.

During the initial experimental stage, it's recommended to extrude the materials multiple times to determine the optimal process. With each extrusion, the material becomes more uniform and transparent.