"目录号: HY-13677
Cell Cycle/DNA DamageAutophagy-
Mercaptopurine (6-mercaptopurine; 6-MP)是免疫抑制剂。
Nucleoside Antimetabolite/AnalogAutophagy
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生物活性
Description
Mercaptopurine (6-mercaptopurine; 6-MP) is an immunosuppressive drug; is a thiopurine.IC50 Value: 149.5±124.9 nM (PBMC blastogenesis) [1]Target: Nucleoside antimetabolitein vitro: Both AZ and 6-MP dose-dependently suppressed PBMC blastogenesis. Mean +/- s.d. IC50 (concentration of drug that gave 50% inhibition) values for AZ and 6-MP were 230.4 +/- 231.3 and 149.5 +/- 124.9 nM, respectively [1]. After incubation of PBMCs with 100 microM AZ for 4 days, 35.3-92.5 microM 6-MP was liberated into the culture medium. in vivo: The conversion of 6-mercaptopurine to 6-thiouric acid was prevented when allopurinol or oxypurinol were added to the lumen. At a luminal drug concentration of 1 mmol/l, allopurinol increased the rate at which 6-mercaptopurine appeared in the serosal secretions by 90% compared with an increase of only 50% with oxypurinol [2]. Combined treatment with 150 R X-rays and 150 mg/kg 6-mercaptopurine gave an additive effect and demonstrated conclusively that the peak incidence of dead implants observed at 30.5 - 35.5 days can be attributed to cells treated [3].Clinical trial: Comparative Pharmacokinetics of a Compounded 6-mercaptopurine Liquid Formulation Preparation and Tablets. Phase not specified
Clinical Trial
Children's Mercy Hospital Kansas City-Midwest Cancer Alliance-Experimental Therapeutics in Pediatric Oncology Program at The Children's Mercy Hospitals and Clinics
Acute Lymphoblastic Leukemia
July 2011
Rigshospitalet, Denmark
Leukemia, Lymphocytic, Acute
December 2007
Phase 2
University of Oxford
Breast Cancer-Ovarian Cancer
May 2011
Phase 2
Roxane Laboratories
Acute Lymphoblastic Leukemia
November 2002
ZonMw: The Netherlands Organisation for Health Research and Development-Radboud University
Inflammatory Bowel Diseases-Crohn Disease-Ulcerative Colitis
September 2007
Sun Yat-sen University
Acute Lymphoblastic Leukemia
July 2008
Phase 4
M.D. Anderson Cancer Center-Pfizer
Leukemia-Acute Lymphoblastic Leukemia
August 2011
Phase 1-Phase 2
University of Southern California
Acute Lymphoblastic Leukemia
July 2004
Phase 2
M.D. Anderson Cancer Center-Amgen
Leukemia-Acute Lymphoblastic Leukemia
November 2016
Phase 2
National Institute of Allergy and Infectious Diseases (NIAID)-National Institutes of Health Clinical Center (CC)
Hermanski-Pudlak Syndrome-Colitis-Cytokines-Lymphocytes-Drug Evaluation
August 7, 2007
Phase 2
M.D. Anderson Cancer Center-Incyte Corporation
Leukemia
July 2015
Phase 2
Sun Yat-sen University
Leukaemia,Lymphoblastic
January 2016
Phase 2
St. Jude Children's Research Hospital-Novartis Pharmaceuticals-Spectrum Pharmaceuticals, Inc
Acute Lymphoblastic Leukemia-Lymphoma, Non-Hodgkin's-Leukemia, T-Cell-Leukemia, B-Cell
November 23, 2016
Phase 2
Rutgers, The State University of New Jersey-National Cancer Institute (NCI)
Acute Lymphocytic Leukemia
February 2001
Phase 2
Ruijin Hospital
Acute Lymphoblastic Leukemia
December 2010
Phase 4
Amgen-Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator-Innovative Therapies For Children with Cancer Consortium
Acute Lymphoblastic Leukemia (ALL)
December 2014
Phase 1
Children's Cancer Group, China-Shanghai Children's Medical Center-Tongji Hospital-West China Second University Hospital-Qilu Hospital of Shandong University-Tianjin Medical University Cancer Institute and Hospital-Children’s Hospital of Sochow University, China-Nanjing Children's Hospital-Xiangya Hospital of Central South University
Lymphoblastic Lymphoma
January 2016
Phase 2-Phase 3
Memorial Sloan Kettering Cancer Center-Baxalta US Inc.-Duke University-Weill Medical College of Cornell University-Lehigh Valley Health Network
Leukemia
August 2013
Phase 2
National University Hospital, Singapore
Acute Lymphoblastic Leukemia (ALL)
October 2008
Phase 4
Johann Wolfgang Goethe University Hospital-Deutsche Krebshilfe e.V., Bonn (Germany)
Adult Acute Lymphocytic Leukemia
April 1993
Phase 4
Johann Wolfgang Goethe University Hospital
Adult Acute Lymphocytic Leukemia
October 1999
Phase 4
Dana-Farber Cancer Institute-Brigham and Women's Hospital-Massachusetts General Hospital-Queen Elizabeth II Health Sciences Centre
Acute Lymphoblastic Leukemia
June 2002
Phase 2
Wyeth is now a wholly owned subsidiary of Pfizer
Leukemia, Myelocytic, Acute
May 2002
Phase 3
Dana-Farber Cancer Institute-Massachusetts General Hospital-Boston Children’s Hospital-NCIC Clinical Trials Group
Acute Lymphoblastic Leukemia
April 2007
Phase 2
Children's Mercy Hospital Kansas City-Midwest Cancer Alliance-Experimental Therapeutics in Pediatric Oncology Program at The Children's Mercy Hospitals and Clinics
Acute Lymphoblastic Leukemia
July 2011
Rigshospitalet, Denmark
Leukemia, Lymphocytic, Acute
December 2007
Phase 2
University of Oxford
Breast Cancer-Ovarian Cancer
May 2011
Phase 2
Roxane Laboratories
Acute Lymphoblastic Leukemia
November 2002
ZonMw: The Netherlands Organisation for Health Research and Development-Radboud University
Inflammatory Bowel Diseases-Crohn Disease-Ulcerative Colitis
September 2007
Sun Yat-sen University
Acute Lymphoblastic Leukemia
July 2008
Phase 4
M.D. Anderson Cancer Center-Pfizer
Leukemia-Acute Lymphoblastic Leukemia
August 2011
Phase 1-Phase 2
University of Southern California
Acute Lymphoblastic Leukemia
July 2004
Phase 2
M.D. Anderson Cancer Center-Amgen
Leukemia-Acute Lymphoblastic Leukemia
November 2016
Phase 2
National Institute of Allergy and Infectious Diseases (NIAID)-National Institutes of Health Clinical Center (CC)
Hermanski-Pudlak Syndrome-Colitis-Cytokines-Lymphocytes-Drug Evaluation
August 7, 2007
Phase 2
M.D. Anderson Cancer Center-Incyte Corporation
Leukemia
July 2015
Phase 2
Sun Yat-sen University
Leukaemia,Lymphoblastic
January 2016
Phase 2
St. Jude Children's Research Hospital-Novartis Pharmaceuticals-Spectrum Pharmaceuticals, Inc
Acute Lymphoblastic Leukemia-Lymphoma, Non-Hodgkin's-Leukemia, T-Cell-Leukemia, B-Cell
November 23, 2016
Phase 2
Rutgers, The State University of New Jersey-National Cancer Institute (NCI)
Acute Lymphocytic Leukemia
February 2001
Phase 2
Ruijin Hospital
Acute Lymphoblastic Leukemia
December 2010
Phase 4
Amgen-Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator-Innovative Therapies For Children with Cancer Consortium
Acute Lymphoblastic Leukemia (ALL)
December 2014
Phase 1
Children's Cancer Group, China-Shanghai Children's Medical Center-Tongji Hospital-West China Second University Hospital-Qilu Hospital of Shandong University-Tianjin Medical University Cancer Institute and Hospital-Children’s Hospital of Sochow University, China-Nanjing Children's Hospital-Xiangya Hospital of Central South University
Lymphoblastic Lymphoma
January 2016
Phase 2-Phase 3
Memorial Sloan Kettering Cancer Center-Baxalta US Inc.-Duke University-Weill Medical College of Cornell University-Lehigh Valley Health Network
Leukemia
August 2013
Phase 2
National University Hospital, Singapore
Acute Lymphoblastic Leukemia (ALL)
October 2008
Phase 4
Johann Wolfgang Goethe University Hospital-Deutsche Krebshilfe e.V., Bonn (Germany)
Adult Acute Lymphocytic Leukemia
April 1993
Phase 4
Johann Wolfgang Goethe University Hospital
Adult Acute Lymphocytic Leukemia
