自从2012年CRISPR-Cas9这项基因编辑技术发明之后，这项技术得到了迅速的发展。它从细菌防域系统中发展而来，可以允许基因材料方便并精准地被编辑。
然而这项技术有主要三个缺点：第一，它代替基因的能力对于那些复制的细胞能够最有效地发挥作用。第二，为了让新材料加入其中它必须首先打破DNA对，从而产生很多意想不到的作用。第三，这种技术并不能有效修正点突变。
针对第三种缺点，其实也有解决的方法，就是改变某些特别的碱基并且不用切开DNA。
Since CRISPR-Cas9, a gene-editing technique has been discovered from 2012, this technique has gone from strength to strength. It was developed from a bacteria defending system and permits genetic material to be edited easily and precisely.
However, it has three flaws. First, its ability of replacing genes works best in those replicating cells. Second, in order to insert new materials into the gap, it has to break the DNA strands first, which will cause undesirable effect. Third, it doesn't work effectly on correcting point mutations. With regard to the third one, there's another way to solve, which can alter specific bases without cutting the DNA strands they are in.
