Ezatiostat

"目录号: HY-13634A

Metabolic Enzyme/Protease-

Ezatiostat 是一种 glutathione 类似物，为谷胱甘肽 S-转移酶 P1-1 (GSTP1-1) 抑制剂。

Gutathione S-transferase

相关产品

Ezatiostat hydrochloride-

生物活性

Description

Ezatiostat is a glutathione analog inhibitor ofglutathione S-transferase P1-1 (GSTP1-1).

In Vitro

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

Clinical Trial

NCT01422486

Telik

Myelodysplastic Syndrome (MDS)

October 2011

Phase 2

NCT01459159

Telik

Myelodysplastic Syndrome (MDS)

October 2011

Phase 2

NCT00909584

Telik

Severe Chronic Neutropenia

April 2009

Phase 2

NCT01062152

Telik

Myelodysplastic Syndrome

November 2009

Phase 1

NCT00701870

Telik

Non-small Cell Lung Cancer

October 2008

Phase 2

NCT00700206

Telik

Myelodysplastic Syndrome (MDS)

May 2008

Phase 2

NCT00280631

Telik

Myelodysplastic Syndrome (MDS)

February 2006

Phase 1-Phase 2

NCT00035867

Telik

Myelodysplastic Syndromes

April 2002

Phase 1-Phase 2

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References

[1].Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.