- To circumvent this issue, it has been proposed to reduce effective population size of the targeted populations in order to increase linkage disequilibrium between markers and QTLs and capture most of the QTLs, a strategy generally known as genomic selection [73-75]. (Prunier et al., 2013)
- To circumvent the difficulty in manipulating a large number of correlated traits, new attempts were made by Mangin et al. (1998) and Korol et al. (2001), who transformed the initial trait space into a space of a lower dimension on the basis of principal component analysis or interval-specific calculation of eigenvalues and eigenvectors of the residual covariance matrix. (Ma, Casella, Wu, 2002)
- This problem may be circumvented in the future by simultaneous analysis of genome-wide changes in expression at all loci in response to single P element mutations that affect a common trait, using expression microarrays. (Mackay, 2001)
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