"目录号: HY-14608A
L-Glutamic acid monosodium salt（Monosodium glutamate） 是mGlu1受体活化剂。
相关产品
CTEP-LY341495-LY354740-LY404039-RG7090-Mavoglurant-MPEP Hydrochloride-Dipraglurant-Topiramate-JNJ-40411813-L-Glutamine-FITM-JNJ16259685-MTEP hydrochloride-(S)-MCPG-
生物活性
Description
L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator ofmGlu1 receptor.
IC50& Target
mGlu1 receptor[1]
In Vivo
A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only <20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1].
References
