将蛋白质组数据聚类分析的一个示例。
Signal transduction through the Mitogen Activated Protein Kinase (MAPK) pathways is evolutionarily highly conserved. Many cells use these pathways to interpret changes to their environment and respond accordingly. The pathways are central to triggering diverse cellular responses such as survival, apoptosis, differentiation and proliferation. Though the interactions between the different MAPK pathways are complex, nevertheless, they maintain a high level of fidelity and specificity to the original signal. There are numerous theories explaining how fidelity and specificity arise within this complex context; spatio-temporal regulation of the pathways and feedback loops are thought to be very important. This paper presents an agent based computational model addressing multi-compartmentalisation and how this influences the dynamics of MAPK cascade activation. The model suggests that
multi-compartmentalisation coupled with periodic MAPK kinase (MAPKK) activation may be critical factors for the emergence of oscillation and ultrasensitivity in the system.
Finally, the model also establishes a link between the spatial arrangements of the cascade components and temporal activation mechanisms, and how both contribute to fidelity and specificity of MAPK mediated signalling.
2016-Plos one-Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity
最后编辑于 ：
©著作权归作者所有,转载或内容合作请联系作者
- 文/潘晓璐 我一进店门，熙熙楼的掌柜王于贵愁眉苦脸地迎上来，“玉大人，你说我怎么就摊上这事。” “怎么了？”我有些...
- 文/花漫 我一把揭开白布。 她就那样静静地躺着，像睡着了一般。 火红的嫁衣衬着肌肤如雪。 梳的纹丝不乱的头发上，一...
- 文/苍兰香墨 我猛地睁开眼，长吁一口气：“原来是场噩梦啊……” “哼！你这毒妇竟也来了？” 一声冷哼从身侧响起，我...
