2018-08-10 L119

A big collaboration is trying to understand diseases of the psyche

Diseases of the psyche have always been slippery things. Schizophrenia, bipolar disorder, major depression and a host of others have no visible markers in the brain. Their symptoms overlap sufficiently that diagnoses may differ between medical practitioners, or even vary over time when given by a single practitioner. In this they are unlike neurological diseases. These either leave organic traces in the brain that, though not always accessible before a patient’s death, are characteristic of the condition in question, or cause recognisable perturbations of things such as electroencephalograms.

The impulse to categorise, though, is enormous—as witness the ever greater number of conditions identified in successive editions of the Diagnostic and Statistical Manual of Mental Disorders, published by the American Psychiatric Association. That is because diagnosis and treatment go hand in hand. But if diagnostic categories are misconceived then treatment may be misapplied. In this context a paper published recently in Science, by a group calling itself the Brainstorm Consortium, is helpful. The consortium has brought together many research groups who work on various psychiatric diseases, as well as on neurological diseases, and has run their collective data through the wringer.

In particular, the consortium’s researchers have looked at what are known as genome-wide As her private secretary he has access to all her correspondence.

Serious students of music must familiarize themselves with the literature and idiom of all the important composers.

John always tries to cultivate people who are useful to him.

Please be careful not to break the precious vase.

A gentleman's agreement is not usually enforceable by law.

I prefer the dry humour of situation comedy to the slapstick of circus clowns.

Why don't you call Suzy? She's a dab hand at organizing barbecues.

I've got a month to reorganize the accounts department. I have my work cut out for me!

The training course was very interesting but the acid test will come when I start my new job.

By studying on the train on the way home, Claire kills two birds with one stone.

We need someone who is really on the ball to head the fund-raising campaign.

When the argument turned into a fight, the bar owner took the bull by the horns and called the police.

John is very intelligent but he can't hold a candle to his brother Paul when it comes to sports.

Meals are always served on time. In their home everything runs like clockwork.

When we launched the new product, we cut the ground from under our competitors' feet.

Another coat of paint should do the trick.

And you know nowadays the camera work is so artificial.

Oh, no. You've got to be careful with complaints, especially when it comes to your roommates.

I've just got the news that you are promoted to manager of the Washington branch of our company.

They also may not want to get themselves annoyed because it's hard for them to calm down.

The mind is the collection of activities based in the brain that involve how we act, think, feel and reason.

I've got a month to reorganize the accounts department. I have my work cut out for me!

The training course was very interesting but the acid test will come when I start my new job.

By studying on the train on the way home, Claire kills two birds with one stone.

We need someone who is really on the ball to head the fund-raising campaign.

When the argument turned into a fight, the bar owner took the bull by the horns and called the police.

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