"目录号: HY-15313B
CBB1007盐酸盐是组蛋白去甲基化酶LSD1高效底物竞争性抑制剂，细胞可渗透，对hLSD1的IC50值为5.27uM。
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GSK-J4-GSK2879552-SP2509-Tranylcypromine hemisulfate-ORY-1001-JIB-04-ML324-IOX1-CPI-455-Daminozide-KDM5-IN-1-CBB1007-DDP-38003 dihydrochloride-KDM5A-IN-1-NCGC00244536-
生物活性
Description
CBB1007 Hcl is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1).IC50 Value: 5.27 uMTarget: hLSD1CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM). CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ≥ 100 μM).
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