Advanced age of a father is correlated with
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For example, a newborn can be diagnosed with fetal alcohol spectrum disorder(FASD), even though the mother has never consumed alcohol, Kitlinska says. “Up to 75 percent of children with FASD have biological fathers who are alcoholics, suggesting that preconceptual paternal alcohol consumption negatively impacts their offspring.”
Advanced age of a father is correlated with elevated rates of certain diseases, and birth defects in his children. A limited diet during a father’s preadolescence has been linked to reduced risk of cardiovascular death in his children and grandchildren. Paternal obesity is linked to enlarged fat cells, changes in metabolic regulation, diabetes, obesity and development of brain cancer. Psychosocial stress on the father is linked to defective behavioral traits in his offspring. And paternal alcohol use leads to decreased newborn birth weight, marked reduction in overall brain size and impaired cognitive function.
“This new field of inherited paternal epigenetics needs to be organized into clinically applicable recommendations and lifestyle alternations,” Kitlinska says. “And to really understand the epigenetic influences of a child, we need to study the interplay between maternal and paternal effects, as opposed to considering each in isolation.”
