Z-DNA binding protein 1 promotes heatstroke-induced cell death
Z-DNA结合蛋白1促进热应激诱导的细胞死亡
abstract
摘要
Heatstroke is a heat stress–induced, life-threatening condition associated with circulatory failure and multiple organ dysfunctions.
热射病是由热应激诱导的，会造成机体循环衰竭和多器官衰竭，威胁到生命的疾病
If global warming continues, heatstroke might become a more prominent cause of mortality worldwide, but its pathogenic mechanism is not well understood.
如果全球变暖持续，热射病可能会成为世界范围内更主要的死亡原因，但是它的致病机制目前还不清楚
We found that Z-DNA binding protein 1 (ZBP1), a Z–nucleic acid receptor, mediated heatstroke by triggering receptor-interacting protein kinase 3 (RIPK3)–dependent cell death.
我们发现Z-DNA结合蛋白1，一种Z核酸受体，通过激活RIPK3受体依赖性的细胞死亡，调控热射病，
Heat stress increased the expression of ZBP1 through heat shock transcription factor 1 (HSF1) and activated ZBP1 through a mechanism independent of the nucleic acid sensing action.
热应激会通过热休克转录因子1（HSF1）增加ZBP1的表达，通过非核酸感应依赖性的一种机制去激活ZBP1，
Deletion of ZBP1, RIPK3, or both mixed lineage kinase domain-like (MLKL) and caspase-8 decreased heat stress–induced circulatory failure, organ injury, and lethality.
ZBP1，RIPK3的缺失，或者MLKL和caspase-8的共缺失会降低热应激诱导的循环衰竭，器官损伤和致死率，
Thus, ZBP1 appears to have a second function that orchestrates host responses to heat stress.
因此，ZBP1可能还有协助宿主对热应激反应的第二个功能
今天好像没做什么事情
早上起得很晚，9点多才爬起来
说实话，我真的不能睡回笼觉
自己真的要好好管一下自己，别轻易放过自己，
如果真的要去一个更好的学校读博士
那真的得好好努力才行 (●'◡'●)
