"目录号: HY-14603
Anti-infectionAutophagy-
Clioquinol(Iodochlorhydroxyquin)是一抗真菌化合物，近来被研究发现有抗AD和抗肿瘤活性。
FungalAutophagy
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生物活性
Description
Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death.
Clinical Trial
NCT00963495
University Health Network, Toronto
Acute Myeloid Leukemia-Acute Lymphocytic Leukemia-Chronic Lymphocytic Leukemia-Myelodysplasia-Lymphoma, Non-Hodgkin-Hodgkin's Lymphoma-Multiple Myeloma
August 2009
Phase 1
NCT01429701
EMS
Eczema
May 2012
Phase 3
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References
[1].Nguyen T, et al. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5.
[2].Cao B, et al. Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Sci Rep. 2014 Jul 18;4:5749.
[3].Katsuyama M, et al. Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. J Pharmacol Sci. 2014;124(4):427-32.
[4].Matlack KE, et al. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8.
