Lagociclovir

"目录号: HY-14846 ee.: 98.13%

Cell Cycle/DNA DamageCytoskeleton-

Litronesib是一种选择性的Eg5变构抑制剂, 这可能破坏有丝分裂, 细胞凋亡, 因此导致肿瘤细胞死亡。

Kinesin

相关产品

ARRY-520-GSK-923295-Ispinesib-Kif15-IN-1-CW-069-Kif15-IN-2-Monastrol-MPI-0479605-SB-743921-Dimethylenastron-EMD534085-PF-2771-Rbin-1-K858-Litronesib Racemate-

生物活性

Description

Litronesib is a selective, allosteric inhibitor of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing.Target: Eg5

References

[1].Wakui H, et al. A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):15-23.