发简信
IP属地：湖北
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文献学习133--Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction1. FMO3 Induces FoxO1 via Its Product, TMAO FMO3在体内的作用机制复杂，难以进行机制研究。因此作者...
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文献学习131--IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis1. IDO1 was closely associated with the cytokine storm phase of sepsis I...
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文献学习130--内皮细胞IDO1通过Kyn调节心梗的心脏功能1. Upregulation of IDO Activity After MI Alters Cardiac Function and Rem...
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文献学习129--GDF15 antagonism limits severe heart failure and prevents cardiac cachexia1. Mice lacking functional PPP1R15A exhibit left ventricular dilated car...
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文献学习128--GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance1. GDF15 Is Induced in Inflammatory Conditions Sepsis患者(病毒感染、细菌感染、细菌病毒感染...
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代谢关键酶
糖代谢 糖酵解：己糖激酶、磷酸果糖激酶、丙酮酸激酶 柠檬酸循环：柠檬酸合酶、异柠檬酸脱氢酶、α-酮戊二酸脱氢酶复合体 戊糖磷酸途径：6-磷酸葡萄...
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文献学习127--PHGDH介导的内皮代谢驱动glioblastoma对CAR-T免疫治疗的耐受磷酸甘油酸脱氢酶（PHGDH）是丝氨酸合成途径中的关键限速酶，催化3-磷酸甘油酸转化为3-磷酸羟基丙酮酸，同时将NAD⁺还原为NADH。 1. ...
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文献学习126--Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence1. p53 Lys120 Acetylation Is a Key Regulator of Endothelial Cell Senesce...
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mTOR信号通路1. mTORC1和mTORC2 mTOR是PI3K相关激酶(PIKK)家族中的丝氨酸/苏氨酸蛋白激酶，形成两个不同的蛋白复合物的催化亚基，称为...