129篇文章 · 323362字 · 29人关注
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文献学习133--Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction1. FMO3 Induces FoxO1 via Its Product, TMAO FMO3在体内的作用机制复杂，难以进行机制研究。因此作者...
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文献学习131--IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis1. IDO1 was closely associated with the cytokine storm phase of sepsis I...
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文献学习130--内皮细胞IDO1通过Kyn调节心梗的心脏功能1. Upregulation of IDO Activity After MI Alters Cardiac Function and Rem...
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文献学习129--GDF15 antagonism limits severe heart failure and prevents cardiac cachexia1. Mice lacking functional PPP1R15A exhibit left ventricular dilated car...
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文献学习128--GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance1. GDF15 Is Induced in Inflammatory Conditions Sepsis患者(病毒感染、细菌感染、细菌病毒感染...
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文献学习127--PHGDH介导的内皮代谢驱动glioblastoma对CAR-T免疫治疗的耐受磷酸甘油酸脱氢酶（PHGDH）是丝氨酸合成途径中的关键限速酶，催化3-磷酸甘油酸转化为3-磷酸羟基丙酮酸，同时将NAD⁺还原为NADH。 1. ...
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文献学习126--Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence1. p53 Lys120 Acetylation Is a Key Regulator of Endothelial Cell Senesce...
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文献学习125--表观水平靶向NPM1通过重编程修复性巨噬细胞代谢促进心梗后心脏修复心肌梗死（MI）不仅会导致显著的心肌细胞功能丧失，还会引发广泛的炎症反应。适度的炎症有助于清除细胞碎片并启动心肌修复，但过度炎症会破坏可挽救的心...
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文献学习124--Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension高血压是全球性的公共健康问题之一，是促进心血管疾病、慢性肾病以及神经系统疾病发展的首要危险因素。内皮功能障碍是高血压促进疾病发生发展的重要机制，...
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